COMBINING HEPATIC PERCUTANEOUS PERFUSION WITH IPILIMUMAB PLUS NIVOLUMAB IN ADVANCED UVEAL MELANOMA (CHOPIN): STUDY PROTOCOL FOR A PHASE IB/RANDOMIZED PHASE II TRIAL

Abstract Background While immune checkpoint inhibition (ICI) has revolutionized the treatment of metastatic cutaneous melanoma, no standard treatments are available for patients with metastatic uveal melanoma (UM).Several locoregional therapies are effective in the treatment of liver metastases, such as percutaneous hepatic perfusion with Long Slee

The striatum is primarily composed of two types of medium spiny neurons (MSNs) expressing either D1- or D2-type dopamine receptors.However, the Muffin Pan Cleaning Brushes fate determination of these two types of neurons is not fully understood.Here, we found that D1 MSNs undergo fate switching to D2 MSNs in the absence of Zfp503.Furthermore, scRNA

Background: Measures of spatial intratumor heterogeneity are potentially important diagnostic biomarkers for cancer progression, proliferation, and response to therapy.Spatial relationships among cells including cancer and stromal cells in the tumor microenvironment (TME) are key contributors to heterogeneity.Methods: We demonstrate how to quantify

Genetic ancestry is known to impact outcomes of genotype-phenotype studies that are designed to identify risk for common diseases in human populations.Failure to control for population stratification due to genetic ancestry can significantly confound results of disease association studies.Moreover, ancestry is a critical factor in assessing lifetim